Drug-Like Properties : Concepts, Structure Design and Methods from ADME to Toxicity Optimization

$245.94 $0.00
( / )
Add to Wishlist

Free delivery worldwide

Receive the books within
3-12 business days.

Why buy from Booksmart ?

Why Buy From Us?
  • 100% Authentic Books
  • Customer Satisfaction is our no. 1 Priority
  • Secure Payment
First Time Buying From Booksmart?Take 10% Off With Code "MyFirst10".
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.
$245.94 $0.00
( / )

Free delivery worldwide

Receive the books within
3-12 business days.

Why buy from Booksmart ?

Why Buy From Us?
  • 100% Authentic Books
  • Customer Satisfaction is our no. 1 Priority
  • Secure Payment
First Time Buying From Booksmart?Take 10% Off With Code "MyFirst10".
Add to Wishlist

Product details

Author: Li Di

Format: Hardback | 580 pages

Dimensions:216 x 276 x 33.02mm | 1,890g

Publication Date: 25 Feb 2016

Publisher: Elsevier Science Publishing Co Inc

Language: English

ISBN 10: 0128010762

ISBN 13: 9780128010761